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pentobarbital will decrease the extent or effect of venetoclax by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the extent or result of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Reduced AUC of tramadol as well as the Lively metabolite (O-desmethyltramadol) when coadmini